3/24/2024 0 Comments Pk meaningMetabolism – Drug can be metabolized, or converted into other chemical species.Įlimination – Drug is removed from the body by a specific organ (e.g. Clearance is a collection of processes by which the body removed the drug from the body. Some might ask, what does it mean to “clear” a drug. This concept is illustrated in the following graph: This means that the rate of elimination (Green line) changes in direct proportion to the concentration of drug measured (Blue line). In most cases, CL is considered to be constant (Red line). Clearance (CL) is a proportionality factor that relates the concentration of drug measured in the body to the rate of elimination. The primary PK parameter clearance is very similar to its friend, volume of distribution. Drug clearance defines how much drug should be administered, how frequently to dose a patient, and how two interacting drugs will affect a patient. Drug clearance is an extremely important topic in the science of pharmacokinetics.
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